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We thank Benjamin Stevens and Pritish Argawal for scientific and technical assistance.
#Goldman fingerprint capture plus#
T1 - Dynein tethers and stabilizes dynamic microtubule plus ends Thus, dynein-mediated capture and tethering of microtubules at the cortex can lead to enhanced stability of dynamic plus ends.", Computational modeling suggests that dynein delays catastrophe by exerting tension on individual protofilaments, leading to microtubule stabilization.
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This effect was ATP dependent, indicating that dynein motor activity was required. In assays with dynamic microtubules, dynein delayed barrier-induced catastrophe of microtubules. Dynein induced a significant reduction in the lateral diffusion of microtubule ends, distinct from the effects of other microtubule-associated proteins such as kinesin-1 and EB1. To explore the mechanism involved, we developed a minimal in vitro system, with dynein-bound beads positioned near microtubule plus ends using an optical trap. Whereas cytoplasmic dynein is primarily known as a minus-end-directed microtubule motor for organelle transport, cortically localized dynein has been shown to capture and tether microtubules at the cell periphery in both dividing and interphase cells. The model posits that selective anchoring of microtubule plus ends at the cell cortex may contribute to cell polarization, spindle orientation, or targeted trafficking to specific cellular domains. These dynamics allow microtubule plus ends to explore cellular space. Thus, dynein-mediated capture and tethering of microtubules at the cortex can lead to enhanced stability of dynamic plus ends.Ībstract = "Microtubules undergo alternating periods of growth and shortening, known as dynamic instability. The "search and capture" model posits that selective anchoring of microtubule plus ends at the cell cortex may contribute to cell polarization, spindle orientation, or targeted trafficking to specific cellular domains. Microtubules undergo alternating periods of growth and shortening, known as dynamic instability.